Postdoc in molecular cell biology and drug discovery at University of Oulu (Finland)

The University of Oulu in Northern Finland, with approximately 16,000 students and 3,000 employees, is an international, multidisciplinary research university with a rich pool of creative and intellectual talent. The strengths of the University include broad, multidisciplinary research interests, a modern research and study environment, and wide cooperation with international research and educational institutes (http://www.oulu.fi/university/).

An open postdoctoral position is available in the field of molecular cell biology within the structural biology research group of  Dr Lari Lehtiö. Focus of the project is human tankyrases, which are ADP-ribosyltransferases controlling cellular signaling events and stability of multiprotein complexes. The project includes structural and cell biology as well as drug discovery aspects.

The position is located at the Faculty of Biochemistry and Molecular Medicine (FBMM), whose mission is to perform internationally significant research and to deliver high-level undergraduate and postgraduate education in the fields of biochemistry and molecular medicine. Research at the Faculty is carried out in 14 research groups. The Faculty has ~200 employees, and approximately half of them are from abroad. Together with Biocenter Oulu, the Faculty has put a great effort towards building a cutting-edge research infrastructure that includes state-of-the-art instrumentation for imaging, gene-modified mice, X-ray crystallography, and quantitative biochemistry. The Faculty has extensive collaborative national and international networks including Biocenter Finland and the ESFRI projects Instruct, EuroBioimaging, and Infrafrontier. We are also a partner in iNEXT and Instruct-ULTRA and organize EMBO workshops and international symposia. The research group has well-established international collaborative networks.

Subject field and description of the position

The research focus for the position within a structural and chemical biology team will be on setting up various cell assays as well as participation to structural and functional studies of human tankyrases and complexes formed with other proteins.

The details of the research project will be mutually agreed upon, based on the qualifications, interests, and expertise of the candidate. Candidates with expertise on structural biology, cell biology or other supporting techniques will be considered.

The duration of the position is 2 years ending in August 31, 2020. The starting date is August 1, 2018, or as soon as possible thereafter.

Required Qualifications and assessment

The successful applicant must hold a PhD degree in cell biology, biophysics, structural biology, biochemistry or a related field. Candidates whose PhD thesis has been submitted by the application deadline will also be eligible. Experience with molecular cell biology, recombinant protein expression different hosts, post-translational modifications, X-ray crystallography and cryo-EM will be considered as assets.

Fluency in both written and spoken English, as well as good communication and teamwork skills are required. Demonstrated experience in writing scientific publications, potential in acquiring supplementary funding and teaching experience will be taken as merits. When assessing the applicant’s qualifications, issues to be considered will include scientific publications, supervision experience, activity in the scientific community and familiarity with the research field.

As part of the FBMM, the duties may also include supervising scientific research of BSc, MSc, and PhD students. Participation in teaching within the faculty curriculum and in acquiring research funding is expected.

A six-month trial period will be effective in the beginning of a 2-year contract that may be extended based on performance and availability of funding.

Salary

The salary will be based on level 5 or 6 of the demand level chart for university-level teaching and research staff of Finnish universities. In addition, a salary component based on personal work performance will be paid (maximum of 46.3 % of the job-specific component). The salary is in practice roughly 3,300 – 4,100 € / month, depending on qualifications, performance, and experience.

Application Procedure

The following documents must be attached to the application (in English):

1) Curriculum vitae including a list of publications

2) Motivation letter with brief description of research merits and experience

3) Contact information of two persons who may be asked to give a statement of the candidate

Applications, together with all relevant enclosures, must be submitted using the electronic application form by 31.5.2018. Applications sent by email will not be considered.

Interview

The top candidates for the post may be interviewed and asked to present their scientific work and experience.

For further information regarding the filling of this post:

Dr Lari Lehtiö, group leader, University of Oulu, Faculty of Biochemistry and Molecular Medicine, email: lari.lehtio(at)oulu.fi

Tiina Hurskainen, HR Manager, email: tiina.hurskainen(at)oulu.fi